Evaluation of the Host-Guest In clusion Complex Formation of Cucur bit [۷, ۸]uril with trans-[{ PtCl(NH۳)۲}۲(ȝ-NH ۲ (CH۲)۸NH۲)]۲+) Anticancer Drug

Multi nuclear platinum complexes developed by farrell an d co-worke rs have shown consid erable prom ise as anti-cancer agents[۱]. The mechanism of these drugs is through the chemical bindings with DNA molecul es which destroys the cancer cells. Recentl y the researchers encapsulated of m ultinuclear platinum complexes by cucurbit[n]uril could r educe their toxicity and protect them from bindi ng by thiol c ontaining proteins[۱,۲].

کلیدواژه ها:

Inclusion Complex ، DFT ، Anticancer drug ، Cucurbit[n]uril