Stratified genome-wide association analysis of blood pressure traits reveal new specific loci for systolic and diastolic blood pressures

Systolic and diastolic blood pressure (SBP and DBP) are complex quantitative traits which are influenced by complex interactions between genetic background and environmental factors. The latest and largest meta–analysis of genome -wide association study (GWAS) of blood pressure traits (SBP and DBP) has identified and validated genomic variants at ۹۰۱ blood pressure–associated loci in total (Evangelou et al. ۲۰۱۸). This genome-wide discovery analyses of blood pressure traits is conducted over a large population of European ancestry (N=۷۵۷,۶۰۱).Despite great success in reporting new loci for blood pressure traits, Evangelou et al. did not report any single nucleotide polymorphisms (SNPs) specifically associated with either SBP or DBP. Traits-specific genomic loci might provide promising potential clues for understanding the underlying biology of complex traits as well as the etiology of complex diseases.

کلیدواژه ها:

Systolic blood pressure ، diastolic blood pressure ، PIK۳CG ، SESN۳ ، genomic loci ، genome -wide association study