Studying the effects of essential oil and extract of Teucrium Polium on cell proliferation of Gastric Adenocarsinoma Cell lines

Gastric cancer is considered the second death cause, which has been poorly developed in prevention and control therapies. In this regard, detecting a significant treatment can be fruitful. Recent studies have shown that chemical medications affect healthy cells in the patient's body adversely. Therefore, new therapies with higher efficacy and fewer side effects, such as medicinal herbs, are considered by researchers. In fact, secondary metabolites in some plants are known as a substantial cure in antioxidant and anticancer treatments. Previous studies have shown that Teucrium polium extract inhibits the proliferation of prostate cancer cells. On this subject, the effects of alcoholic and methanolic extracts of T. polium plant, which we obtained from the mountains around Yasuj city, were evaluated as a potential treatment for human Gastric cancer cure via this research. The results show that ethanolic, methanolic and essential oil of T. Polium have had the cytotoxic effect on AGS cells. According to the results of MTT and flow cytometry, it appears that the anticancer compounds in the T. polium extract likely regulate the cell cycle, stimulate the Tumor suppressor proteins, inhibit cells to grow, and cause cancerous cells to death as well.

کلیدواژه ها:

Gastric cancer ، Teucrium Polium ، MTT ، flow cytometry ، essential oil ، herbal medicine