HN-01440126_Synbiotic Supplementation Effect on Muscle Wasting in Critically Ill Patients: A Randomized Controlled Trial

Introduction Muscle wasting is associated with negative health outcomes such as functional disability, higher risk of infections, delayed recovery and mortality in critical care patients. The aim of this study was to evaluate the effect of gut microbiota modulation through synbiotics on muscle wasting in critically ill patients.Methods: This was a double-blind, randomized controlled trial conducted in Mashhad, Iran. All eligible patients (20 subjects in each group) received standard hospital gavage as enteral nutrition through a nasogastric tube. In the intervention group, patients received Lactocare (ZistTakhmir) capsules 500 mg every 12h for a maximum of 14 days. Patients in the control group received a placebo capsule, similarly. Mid-arm circumference (MAC) and 24-hour urine creatinine excretion were measured before and after the treatment. Data were analyzed via SPSS statistical software version 16.Results: A total number of 38 patients (mean age 42.82 years) completed at least four days of the intervention (mean 10.29 days). At baseline, both groups were similar regarding age, disease severity, nutritional risk and energy and proteinintake. Although MAC was significantly reduced in the placebo group (26.60±5.5 to 24.3±5.45, p<0.001), there was no significant change in the synbiotic group (28.75±2.60 to 28.15±2.93, p=0.16). 24-hour urine creatinine, which is associated with body muscle mass, showed a non-significant increase in the synbiotic (348.66±116.12 to 460.44±153.40) and a non-significant decrease in the control group (585.60±195.25 to 300.54±100.18).Conclusion: Overall, it can be concluded that synbiotic supplementation can be beneficial in muscle mass maintaining in critically ill patients.

کلیدواژه ها:

critical care ، muscle wasting ، synbiotic