Transgenerational Effects of Paternal Spatial training on male offpring Spatial Learning

سال انتشار: 1398
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 311

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شناسه ملی سند علمی:

NSCMED08_584

تاریخ نمایه سازی: 15 دی 1398

چکیده مقاله:

Lamarck’s idea of the ability for transferring memories acquired in the face of various environmental conditions through non-educational and non-genetic mechanisms to children has been greatly considered [Junien et al., 2016]. Previous studies have shown that the environmental experiences of parents, such as the exposure to environmental toxins, educational behaviors, stress and fear may affect the phenotypes of several generations [Arai and Feig, 2011; Azadi et al., 2019; Dias and Ressler, 2014; Lim and Brunet, 2013]. the inheritance of epigenetic patterns including DNA methylation, histone modification, and non-coding RNA to living organisms allows the information related to the ancestral environment to be passed on to their offspring [Wang et al, 2017]. Presently, the acquired traits related to the learning and memory capabilities are among the most important issues in the field of epigenetic transmission. Considering that methylation DNA, histone methylation and histone acetylation are three major epigenetic processes involved in the regulation of memory which leads modification of epigenetic patterns, and given the possibility of transmitting epigenetic symptoms from parents to offspring, it is anticipated that the phenotypes created in the learning process and memory formation in parents will be passed on to their children, which facilitates the learning process and memory formation of the offspring. The present study investigated whether paternal learning of the spatial task before fertilization can facilitate the learning process of spatial memory tasks in their male offspring by the Morris water maze test.In the present study, Adult male (8 weeks old) were used at the beginning of the study. The first eight male rats were randomly divided into two groups: spatial memory training group (n=4) and control group (n=4). The rats participated in the spatial memory training group in the Morris water maze Protocol and the control group did not participate in any training. After the end of the training session, male rats of both groups mated with female rats that had not experienced any training. After the end of mating, pregnancy, birth and lactation, Four male offspring from each mother was randomly selected in each group and in the two groups paternal train (n=16) and paternal no-train (n=16) they were practicing Morris water maze within 5 days.The results of ANOVA with repeated measurement showed that the main effect of trials (F11, 330=19.63, p≤0.001), main effect of group (F11, 30=11.77, p≤0.01) and Interactive effect of trials and group (F111, 330=1.98, p≤0.032) is significant. The results of post-hoc test showed that in trials 5 there was a significant difference between the time to find the platform in the paternal train and paternal no-train groups, and male offspring of paternal train group had better performance. Also, the independent t-test results showed that in the probe test the male offspring of paternal train was significantly better than the male offspring of paternal no-train.Parental spatial training before fertilization facilitates the spatial learning and memory in their male offspring.

نویسندگان

Javad Riyahi

Department of Behavioral and Cognitive Science in Sport, Faculty of Sport Sciences and Health, Shahid Beheshti University, Tehran, Iran

Behrouz Abdoli

Department of Behavioral and Cognitive Science in Sport, Faculty of Sport Sciences and Health, Shahid Beheshti University, Tehran, Iran

Abbas Haghparast

Neuroscience Research Center, School of Medicine, Shahid Beheshti University of Medical sciences, Tehran, Iran

Laura Petrosini

Santa Lucia Foundation, Rome, Italy