Interaction effects of intra-hippocampal injection of citalopram with steroidal hormones on motor memory behavior in the male Wistar rats

Background and Aim : Citalopram, RS-citalopram, is an antidepressant drug from the group of serotonin reuptake inhibitors that is used to treat mood disorders and to treat severe depression disorders. In addition to having significant effects on the treatment of depression, memory is also slightly affected, but still paths It is not known The purpose of the present study was to investigate the interaction of intra-hippocampal injection of citalopram and steroid humans, including estrogen and progesterone on equilibrium memory.Methods : The effect of RS-citalopram on hysterectomy of male Wistar rats was evaluated using stereotaxis Surgery to study the memory process. Then, using equilibrium memory rotarod, the data were analyzed by SPSS software and tukey post hoc test.Results : The results of this study showed that citalopram significantly increased the balance of memory in male Wistar rats compared to the control group. But when combined with steroid hormones, it causes the loss of balance.Conclusion : Intra-hippocampal injection of citalopram has been shown to increase memory and learning in the mice receiving the drug. On the other hand, citalopram when accompanied by steroid hormones, reduces memory and suggests that citalopram interferes with the pathway of steroid hormones.

کلیدواژه ها:

Memory ، Hippocampus ، Male Rats ، Escitalopram