Adapted MMSE and TYM cognitive tests: how much powerful in screening for Alzheimer s disease in Iranian people

سال انتشار: 1398
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 411

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شناسه ملی سند علمی:

NSCMED08_067

تاریخ نمایه سازی: 15 دی 1398

چکیده مقاله:

Background and Aim : Alzheimer s disease (AD) is a major global health priority and providing an efficient way for early diagnosis of people developing dementia is important. The Mini-Mental State Examination (MMSE, total score = 30) and Test Your Memory (TYM, total score = 50) are widely used as screening tests for cognitive function.Methods : In the present study 174 subjects including healthy people (CON group) and those having Alzheimer s disease (AD group) were introduced to MMSE and TYM cognitive tests adjusted to Iranian population. Sensitivities and specificities with optimal cut-off scores, area under curve (AUC), positive predictive value (PPV) and negative predictive value (NPV) were measured for both tests.Results : The MMSE scores of the CON and AD groups were 23.77 ± 0.327 and 10.88 ± 0.762, respectively. The TYM scores were 44.32 ± 0.389 and 14.37 ± 1.368 in the CON and AD participants, respectively. Findings in the MMSE test were: AUC = 0.962, optimal cut-off score = 18.5, sensitivity = 0.90 and specificity = 0.96. Values in the TYM test were: AUC = 0.991, optimal cut-off score = 31, sensitivity = 0.90 and specificity = 1. We found no correlation between the cognitive performance and age in the CON group but a positive correlation in the AD patients. On the other hand, t-test analysis indicated that achievement of the test scores are significantly sex dependent, with more scores attained by the females.Conclusion : Taken together, in regard to correct classification rate (CCR); the TYM test seems to be more appropriate for cognitive screening in our study. However, considering an analogous AUC, both tests are comparable and have high sensitivity and specificity for discriminating between people with and without AD.

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نویسندگان

Azam Alinaghipour

Department of Physiology School of Medicine , Tehran University of Medical Sciences , Tehran , Iran

Mahmoud Salami

Physiology Research Center , Kashan University of Medical Sciences , Kashan , Iran

Reza Daneshvar

Department of Neurology School of Medicine , Kashan University of Medical Sciences , Kashan , Iran

Gholam Ali Hamidi

Physiology Research Center , Kashan University of Medical Sciences , Kashan , Iran