The comparison of dietary intakes of antioxidants in children with ADHD and healthy control; a case-control study

سال انتشار: 1398
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 310

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شناسه ملی سند علمی:

NSCMED08_025

تاریخ نمایه سازی: 15 دی 1398

چکیده مقاله:

Background and Aim : Recent studies have identified ADHD as an inflammatory condition with immunological and oxidative responses. In addition to inflammatory and i mmunologic factors, researchers suggested that oxidative metabolism may be involved in the development of ADHD. Some cross-sectional studies have found that oxidative balance is impaired in patients with ADHD. The relationship between nutrients (macronutrients and micronutrients) and the immune system has always been relevant; some nutrients are known as immune system regulators and others as pro-inflammatory or anti-inflammatory agents. Few studies have been carried out on the role of food antioxidants in ADHD. The plasma levels of micronutrients such as zinc and copper, which play an essential role in the antioxidant defense mechanism, are lower in ADHD children than in healthy people Therefore, it is necessary to examine these factors in the patients.Methods : This study was a retrospective case-control study with 200 ADHD children and 300 healthy children in control group aged 4 to 12 years. The demographic questionnaire, FFQ, and Baecke physical activity questionnaire were used. Dietary intakes of antioxidant including of zinc, selenium, vitamin E, vitamin C and beta-carotene obtain by NUTRITIONIST 4 software from Food Frequencies Questionnaire.Results : There was no significant difference between the two groups as regards age, sex, weight, height, body mass index (BMI). In the case group, the mean the physical activity score (P=0.04) was higher than they were in the control group (P=0.001). Mean ± SD all of antioxidants contents in healthy group were higher than children with ADHD but for zinc and vitamin E were significantly. (P= 0.023 and P = 001 respectively). Other variables were not significant predictors.Conclusion : The present study showed that the dietary intakes of antioxidants in the healthy group were higher than the ADHD children. Based on such evidence, researchers have suggested that oxidative stress might be important in the pathophysiology of ADHD. The findings of some studies showed that elevated oxidative stress increases the release of dopamine, a crucial neurotransmitter in ADHD, by increasing in membrane permeability to calcium ions. Our study shown that dietary intakes of zinc and vitamin E in children with ADHD lower than healthy children significantly. Zinc may plays a pivotal role in the cell growth and cognitive evolution of children and its levels are high in sections of the brain responsible for structural and functional duties. In addition, vitamin E, which has antioxidant effects by reducing lipid peroxidation that may has beneficial effects on ADHD patients.

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