Anti-tubercular behavior of Silver and Zinc Oxide Nanoparticles versus Clinical strains of moltidrug - resistant Mycobacterium tuberculosis

Increased dissemination of multidrug-resistant Mycobacterium tuberculosis has become a huge challenge throughout the world and there is an insistent need to discover novel anti-tubercular compounds. The chemical reduction and deposition methods were carried out to synthesis of nanoparticles. In addition, the MICs and MBCs values was determined via micro-plate alamar blue and proportion assay, respectively. The results showed, by mixing the silver and zinc oxide nanoparticles, anti-tubercular property was increased versus multi-drug resistance. Besides, controlling of bacteria concentration will switch anti-tubercular impact of nanoparticles. However, nanoparticle seems that had cell toxicity behavior

کلیدواژه ها:

Anti-tubercular ، Mycobacterium tuberculosis ، Multi-drug resistance ، Silver ، Zinc oxide ، Nanoparticle