The remedial property of Descurainia sophia in the treatment of fatty liver disease: A histopathological and biochemical approach

In this study, 60 rats were used. A total of 10 rats were chosen as the negative control, and the rest of them were treated with a high-fat diet for four months. Then, the animals were randomly divided into six subgroups, including negative healthy control, untreated negative control, and four groups receiving the aqueous extract of D. sophia at 20, 40, 80, and 160 mg/kg concentrations. After two months, the rats were sacrificed and blood and liver samples of them collected for biochemical and histopathological parameters analysis. The quantitative data were analyzed by SPSS-21 software using one-way ANOVA followed by Duncan test. To analyze the histological data, the Kruskal-Wallis test was run. Findings: All doses of D. sophia could significantly (p<0.05) decrease the raised levels of ALP, AST, ALT, GGT, cholesterol, LDL, triglyceride, total and conjugated bilirubin, and glucose, and increased HDL, total protein, albumin, SOD, and CAT as compared to the untreated group. Also, aqueous extract of D. sophia decreased the degree of hepatic steatosis as compared to the untreated group. Conclusion: The obtained results demonstrated the hepatoprotective effect of aqueous extract of D. sophia

کلیدواژه ها:

Descurainia Sophia ، aqueous extract ، fatty liver disease.