THE HEALTHY NORDIC DIETARY PATTERN HAS NO EFFECT ON INFLAMMATORY MARKERS: A SYSTEMATIC REVIEW AND META-ANALYSIS OF RANDOMIZED CONTROLLED CLINICAL TRIALS

Background and Aim: The present systematic review and meta-analysis aimed to summarize the published evidence provided by randomized controlled clinical trials regarding the effect of the Nordic dietary pattern on circulating inflammatory markers such as C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α).Methods: PubMed, ISI Web of Science, Scopus, and Google Scholar were searched up to October 2017 to identify the relevant studies,. The risk of bias in included studies was assessed using Cochrane collaboration s tool. The overall effects were calculated using the random effects model. Results: Seven studies were eligible to be included in the systematic review. All studies were conducted in Nordic countries. The meta-analysis of six eligible clinical trials which included 613 adult participants showed that adherence to the Nordic diet does not significantly affect circulating CRP levels [weighted mean difference (WMD) = -0.17 mg/l, 95% CI: -0.69, 0.35, P = 0.529]. The meta-analysis of three studies which reported the effect for other inflammatory makers also failed to find any significant effect on TNF- (WMD = 0.23 mg/l, 95%CI: -0.75, 1.21, P = 0.645) and IL-6 (WMD = 0.13 mg/l, 95%CI: -0.29, 0.56, P = 0.539) concentrations.Conclusion: Adherence to the Nordic dietary pattern does not seem to affect circulating CRP, IL-6 and TNF-α levels. Clinical trials with longer follow-up and including participants from other regions are highly recommended.

کلیدواژه ها:

Nordic Diet ، Baltic Sea Diet ، Inflammatory Markers ، CRP ، IL-6 ، TNF-α ، Systematic Review ، Meta-analysis