G1359A VARIANT OF THE CANNABINOID RECEPTOR GENE (RS1049353) AND OBESITY-RELATED TRAITS AND RELATED ENDOPHENOTYPES: A META-ANALYSIS

Background and Aim: This study aimed to investigate the comparison of G1359A variant of cannabinoid receptor gene (rs1049353) with obesity-related traits including body mass index (BMI), fat mass (FM), fat-free mass (FFM), food-related traits, and leptin among healthy and non-healthy adults.Methods: We searched PubMed, Cochrane, Scopus, Web of Science, and EMBASE until December 2016 for observational studies assessing each of the anthropometric measurements, food-related traits, and leptin of 1359 G/A polymorphism of CNR1 gene. A total of 22 studies were included in the meta-analysis comparing mean and standard deviation differences of the anthropometric measurements, leptin, and dietary intake between GA/AA and GG genotypes. Results: The results showed that subjects with GA/AA genotype had significantly lower BMI (weighted mean difference (WMD) =-0.59 kg/m2, p<0.001) compared to those with GG genotype. Dietary intake of fat, carbohydrate, and protein as well as serum levels of leptin were not significantly different between GA/AA and GG genotypes.Conclusion: It was revealed that subjects with mutant polymorphism (GA/AA) of CNR1, compared to the wild-type group (GG), had lower BMI (although there was unexplained heterogeneity).

کلیدواژه ها:

Cannabinoid receptor gene ، polymorphism ، BMI ، dietary intake