The Effect of L-arginine Supplementation on Blood Pressure in Patients with Type 2 Diabetes: A Double-Blind Randomized Clinical Trial

Background: The prevalence of hypertension in patients with type 2diabetes (T2D) is approximately twice as much as healthy people. Thisstudy was designed to determine the effect of L-arginine supplementationon blood pressure in patients with T2D. Methods: In a double-blindrandomized clinical trial, 75 T2D were randomly divided into three groups(3 g/d and 6g/d of L-arginine and placebo) for 3 months. Height, weight,waist circumference, dietary intake, and blood pressure (BP) were measuredbefore and after intervention. Results: In patients who received 3g/d Larginine,no significant difference was observed between BP before andafter the intervention, however, subgroup analysis among patients with highBP showed significant reduction in systolic (P = 0.036) and diastolic BP (P= 0.027) after L-arginine supplementation. After 3 months of intervention,systolic and diastolic BP were significantly different compared to thebaseline values and also with placebo value in patients receiving 6g/d of Larginine(P < 0.05). Conclusions: The daily intake of 6g of L-arginine for 3months in T2D may improve BP. Taking 3g/d of this supplement may helpto improve BP only in patients with hypertension.

کلیدواژه ها:

L-arginine ، Diabetes ، Blood pressure ، Clinical trial