Sara Asadi - MSc, Nutrition and Food Security Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran- Fasa University of Medical Sciences and Health Services, Fasa, Iran
Hassan Mozaffari-Khosravi - PhD, Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran- Yazd Diabetic Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Mohammad Mahdi Naghizade - MSc, Fasa University of Medical Sciences and Health Services, Fasa, Iran
Azadeh Nadjarzadeh - PhD, Nutrition and Food Security Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran- Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

Background: The prevalence of hypertension in patients with type 2diabetes (T2D) is approximately twice as much as healthy people. Thisstudy was designed to determine the effect of L-arginine supplementationon blood pressure in patients with T2D. Methods: In a double-blindrandomized clinical trial, 75 T2D were randomly divided into three groups(3 g/d and 6g/d of L-arginine and placebo) for 3 months. Height, weight,waist circumference, dietary intake, and blood pressure (BP) were measuredbefore and after intervention. Results: In patients who received 3g/d Larginine,no significant difference was observed between BP before andafter the intervention, however, subgroup analysis among patients with highBP showed significant reduction in systolic (P = 0.036) and diastolic BP (P= 0.027) after L-arginine supplementation. After 3 months of intervention,systolic and diastolic BP were significantly different compared to thebaseline values and also with placebo value in patients receiving 6g/d of Larginine(P < 0.05). Conclusions: The daily intake of 6g of L-arginine for 3months in T2D may improve BP. Taking 3g/d of this supplement may helpto improve BP only in patients with hypertension.

L-arginine; Diabetes; Blood pressure; Clinical trial