Reviewing The Effects of Metformin on Ovulation of Women Diagnosed With Polycystic Ovary Syndrome (PCOS)

Backgournd: PCOS is the most common endocrinedisorder among women. Some of the symptoms include anincrease in androgenic hormones,hyperinsulinemia, anovulation, infertility, and obesity. One of the effective yetcontroversial drugs used for ovulation and infertility among these patients is metformin. This article aims at providing a thorough review of the effects of metformin on the ovulation of women diagnosed with PCOS.Methods: This study was conducted reviewinga total number of fifty papers extracted from the following websites: Pubmed,GoogleScholar, Web of Science, Science Direct, Scopus,Magiran,Sid. The papers were chosen searching the keywords PCOS, metformin, and ovulation and were published from 2000 to 2017.Results: The results indicated that using metformin is proven to be helpful for the women diagnosed with oligomenorrhea and PCOS. It increases theabundance of ovulation and reduces the cardiovascular diseasesrisk factors. Moreover, different studies confirm the fact that among women diagnosed with PCOS whose symptoms were treated with Metformin for more than six months the level of  LH, ovarian androgens, and sex hormone binding was reduced. It was also found that ovulation, ovary functioning,and insulin resistance is corrected among these patients. It is worth mentioning that, increasing the dose of metformin can be recommended for those patients whodo not respond to the treatment with metformin at all.  .Discussion and Conclusion: According to the resultsutilizingmetformin increases the effects of insulin and reduces the level of androgen among women diagnosed with PCOS.Consequently, one could argue that treatment with metformin can result in a regular menstruation and ovulation among these patients.

کلیدواژه ها:

Polycystic Ovary Syndrome (PCOS) ، Metformin ، Ovulation