The Effect of Salvia Officinalis Extract on Oxidative Stress Parameters and Insulin Level In Women With Polycyctic Ovary Syndrome: A Randomized, Controled Clinical Trial

Background: Insulin resistance and oxidative stress (OS) are very common findings among patients with polycystic ovary syndrome.Objective: The aim of this study was to evaluate the effects of Salvia officinalis alcoholic extract on OS parameters and Insulin level in woman with PCOSSetting: Academic Medical Centers Affiliated to Iran University of Medical Sciences Methods: This research was conducted with the approval of the Ethics Committee of Iran University of Medical Sciences . In the current randomized, Triple-blind, controlled trial, 60 patients diagnosed with PCOS according to Rotterdam Criteria were randomized to take either 300mg oral S.officinalis extract (n=30) or placebo (n=30) for 8 weeks. Serum fasting insulin level, malonyldialdehyde (MDA) concentration and Total Antioxidant Capacity (TAC) were measured once before and once after intervention. The data analyzed using SPSS software version 18. Results: Fasting insulin and MDA level was significantly decreased in intervention group (P=0.005 and P=0.001 respectively) and TAC increased (P=0.007) after the 8 weeks of taking S.officinalis extract. Conclusion: S.officinalis seemed to decrease oxidative stress and fasting insulin level in PCOS patients

کلیدواژه ها:

Polycystic Ovary Syndrome ، Metabolism ، Insulin ، Oxidative Stress ، Salvia officinalis ، Lamiaceae family