The effect of evening primrose oil on changes in sex hormones, serum glucose and insulin levels in polycystic ovary syndrome (PCOS) induced by estradiol valerate

Background: Polycystic ovary syndrome (PCOS) is one of the most important reproductive and endocrine disorders in women. The aim of this study was to evaluate the effect of evening primrose oil on changes in sex hormones, serum glucose and insulin levels in polycystic ovary syndrome.Methods: A number of 30 female Sprague Dawley rats with regular sexual cycle were divided into five groups (n = 6). Group A: control. Group B: (control treatment) received evening primrose oil gavage (100mg/kg) for 21 days. Group C: PCOS induced by estradiol valerate. Group D: After induction of PCOS received evening primrose oil gavage (100mg/kg) for 21 days. Group E: After induction of PCOS received evening primrose oil gavage (200mg/kg) for 21 days. Finally, blood samples were collected from heart and then sex hormones and glucose and insulin concentrations were determined. The data were analyzed by using SPSS 22 software with statistical method of the one-way ANOVA.Result: FSH levels in the fourth and fifth groups showed a significant increase compared to the third group. LH and testosterone levels in the fourth and fifth groups were significantly lower than those of the third group. The hormone insulin and glucose concentrations in the fourth group were significantly lower than those of the third group.Conclusion: Evening primrose oil can improve sexual performance and also reduce the insulin and glucose levels in polycystic ovary syndrome.

کلیدواژه ها:

Evening primrose oil ، Glucose ، Insulin ، Sex hormones ، Polycystic ovary syndrome