Stem Cells and the Reproductive System disorders:

Several updates in stem cell biology have presented new opportunities for the treatment of reproductive disease. Recent findings show a hypothetical mechanism of endometrial regeneration which can be driven by bone marrow derived stem cells. This finding has potential implications for the treatment of uterine disorders like Asherman syndrome and thin endometrium. It also supports a new theory for the etiology of endometriosis: ectopic transdifferentiation of stem cells.On the other hand against the long held dogma of embryologically fixed numbers of oocytes, current literature suggests that human ovaries contain stem cells which are responsible for adulthood folliculogenesis form new oocytes which provides the potential recovery of such condition like POF (premature ovarian failure) women.Stem cell based therapy provides the potential recovery of spermatogenesis following cancer therapy. Study on animal model of non-obstructive Azospermia shows that BMSCs might offer alternative treatment for the patients with azospermatic infertility after cancer chemotherapy.While we are just beginning to understand stem cells and many key questions remain, the potential advantages of stem cells in reproductive biology and medicine are apparent.

کلیدواژه ها:

Asherman syndrome ، POF ، Reproductive system ، Stem cell ، Thin endometrium