The study of the role of Δ133p53 isoform in associated with Helicobacter pylori in gastric cancer

Δ133p53 isoform encoding from the internal promoter that it contains a region between intron 3 and intron 4 of p53 gene and it is an amino terminally truncated protein. In this isoform, all trans-activation domain and the part of the DNA-binding domain has been deleted. Recently, the pattern of expression of Δ133p53 studied in various tissues of the stomach that it showed increased expression of Δ133p53 along with chronic inflammations for tumorigenesis. The studies show that Helicobacter pylori interactions with gastric epithelial cells, through the cag pathogenicity island, does induces Δ133p53 isoform by c-Jun phosphorylation and activation of activator protein-1-dependent transcription in human cells.Δ133p53 can increase NF-κB transcription and expression of its target genes and it can inhibit the transcriptional activity of the p53 gene, thereby it increase the survival of epithelial cells that infected with Helicobacter pylori. Studies also show that Δ133p53 inhibit P53 dependent transcription from P21 promoter in competition with p68. Generally the results offer a unique insight into the regulation of P53 protein and it may help to an understanding of tumorigenesis associated with Helicobacter pylori. Therefore Δ133p53 as one of the isoforms P53 may be a suitable and promising target for diagnosis, treatment and prognosis of gastric cancer in the future. Since the real mechanism of isoforms due to complex regulation of P53 function is not known completely, therefore, in future studies explore of isoforms will should be under the background of the entire P53 signal path and the interaction between other paths

کلیدواژه ها:

gastric cancer ، Δ133p53 isoform ، Helicobacter pylori