Effect of different amount of nano-cellulose in drug release behavior of PEG hydrogel nano-composite For wound dressing application

سال انتشار: 1395
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 423

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شناسه ملی سند علمی:

CAAT06_056

تاریخ نمایه سازی: 4 مهر 1396

چکیده مقاله:

In recent decades growing trends have been observed towards the use of PEG composites based nano- cellulose in drug delivery systems for wound dressing application. This study considered to evaluate the release of Tetracycline hydrochloride via PEG hydrogel Nano-composite and to assess the effect of different amount of nano-cellulose on release behavior. Reaction carried out by dissolving of reactants in 30 ml distilled water and placing into the water bath at 65℃ for gelation. The samples have been characterized by SEM and release behavior were studied by spectrometric methods at different nano-cellulose proportions(1-4 wt%).The optimum synthesized hydrogel Nano-composite showed 6% drug release for 6 hours at 30℃ with 3% of nano-cellulose. Also it observed that drug release decreased by an increase in the percentage of nano-cellulose till 3% and at 4% of filler the release increased again. Moreover, SEM images showed homogeneous morphology of Nano-composite .Taken together, results implicated that the constructed hydrogel Nano-composites can improve the antibiotic treatment.

نویسندگان

Mohammad Jafar Rezayani

MSc of polymer engineering, Arak University

Seyed Mohammad Tash Shams Abadi

MSc of polymer engineering, Arak University

hossein soleimani

Isfahan University of technology