A cellulose-based Photodynamic Platform for Bacterial Inhibition

Curcumin has long been utilized as a natural antibacterial agent and as a photosensitizer in bacterial photodynamic therapy; however, its clinical applicability is markedly restricted by its poor aqueous solubility, chemical instability, and low bioavailability. Accordingly, this study aimed to design and synthesize a novel curcumin-based hybrid. Curcumin (Cur), a hydrophobic polyphenol derived from the spice turmeric, has been considered as a potential photosensitizer for PDT with evoked immune response, excellent safety, and low cost. However, the translation of curcumin in clinical cancer therapy suffers from an insufficient therapeutic dose in tumor tissues due to its poor solubility and low bioavailability. In this study, carrier-free curcumin nanodrugs (Cur N) were prepared without using any toxic solvents. Cur N exhibited distinct optical properties, light sensitive drug release behavior, resulting in increased reactive oxygen species (ROS) generation and PDT efficacy compared with free Cur.

کلیدواژه ها:

Escherichia coli ، Cellulose nanowhisker ، β-cyclodextri ، Photodynamic