SYNTHESIS OF 1,2,3,4-TETRAHYDROPYRIMIDIN-ONE USING N-ZRO2

An environmentally and straightforward Biginelli based condensation reaction of different aromatic aldehydes, ethyl acetoacetate and urea utilized by nano-ZrO2 to afford 1,2,3,4-tetrahydropyrimidin-one is described. This procedure promoted under thermal conditions at 140 ºC which benefits from simplicity of work-up, low cost reagents and good to high yields

کلیدواژه ها:

Condensation reaction ، 1 ، 2 ، 3 ، 4-tetrahydropyrimidin-one ، Aromatic aldehydes ، Nano-ZrO2