miR-۳۷۵ as a key regulator of insulin secretion and diabetes progression

miR-۳۷۵ is a small RNA that is highly expressed relatively specifically in pancreatic beta cells. This microRNA is essential for normal pancreatic development and affects the number of beta and alpha cells. This RNA plays a key role in glucose-regulated insulin secretion, which it accomplishes by regulating the genes Mtpn and Pdk۱. In addition, miR-۳۷۵ affects genes related to pancreatic development and insulin secretion, making it a potential target for diabetes treatment. This review aims to gather evidence on how miR-۳۷۵ regulates insulin secretion and diabetes progression due to its significant role in diabetes. This review focuses on the role miR-۳۷۵ in beta cell function, including its effects on development and differentiation, proliferation, and regulation of insulin secretion. According to the data of the studies, the change of miR-۳۷۵ expression is likely to play a significant role in the onset and progression of diabetes. It also discusses the regulation of miR-۳۷۵ expression, miR-۳۷۵ as a potential circulating biomarker in type ۱ and type ۲ diabetes, and the need for beta cells to maintain miR-۳۷۵ expression at optimal levels. Therefore, miR-۳۷۵ can be used as a biomarker for early diagnosis of diabetes and as a therapeutic target. Despite all the evidence, further prospective studies are still needed to validate the clinical application of this microRNA.

کلیدواژه ها:

Diabetes ، Insulin ، MicroRNAs