Solid phase extraction of acetaminophen by magnetic expanded graphite sorbentfunctionalized with glycine and its quantitative determination by gold-silver nanoparticlefunctionalized with polyethyleneimine as a colorimetric sensor

A solid phase extraction method using magnetic expanded graphite sorbent was proposed for theseparation and preconcentration of acetaminophen. The effect of important parameters on the extraction ofanalyte was studied and optimized. The extracted acetaminophen was measured by gold-silver nanoparticlefunctionalized with polyethyleneimine as a colorimetric sensor. The linear range was achieved in the range of۰.۱-۲۰.۰ μg L-۱ for acetaminophen (R۲ = ۰.۹۹۷۲) with a limit of detection of ۰.۰۲۹ g L-۱. The intra-and inter-dayrelative standard deviations for six measurements at the concentration level of ۵.۰ μg L-۱ acetaminophen werefound to be ۲.۶ and ۴.۲ % respectively

کلیدواژه ها:

Acetaminophen ، Expanded graphite ، Gold-silver nanoparticles ، Magnetic sorbent