Determination of Helicobacter Pylori Infection Prevalence by Non-invasive Methods

Background: Helicobacter pylori (H. pylori) is identified as the most frequent agent of bacterial infections in humans which can cause various gastrointestinal diseases. This pathogen has infected approximately half of the world’s population, and its outbreak has varied across different regions. The purpose of this study was to estimate the H. pylori infection prevalence amongst patients in Fardis county, Alborz province, Iran, using noninvasive methods. Methods: A total of ۵۶۷۷ patients were analyzed from September ۲۰۲۰ to October ۲۰۲۱ to detect H. pylori by the use of enzyme-linked immunosorbent assay (ELISA) IgG, IgA, and IgM tests, stool antigen test (SAT), and urea breath test (UBT). Results: Of ۵۶۷۷ patients, ۳۴۸۶ (۶۱.۴%) were female and ۲۱۹۱ (۳۸.۶%) were male with the mean age of ۳۸.۸۲ ± ۱۸.۲۸۹ years old. The overall rate of H. pylori infection positive was ۳۱.۴۶%, and the serological tests were the most prescribed types of tests. The IgG test and then SAT detected the most positive cases. Further, the infection rate was significantly associated with age. Except for the case of IgM, which was higher in females compared to males, no significant difference was found between gender and bacteria outbreak. Conclusions: This study indicated a decline in H. pylori infection prevalence compared with the prior survey conducted at this center. However, its rate amongst the patients referring to Fardis laboratory is still high.

کلیدواژه ها:

Helicobacter pylori ، Enzyme-linked immunosorbent assay ، IgA ، IgM ، IgG ، Stool antigen test ، Urea breath test