Synthesis and characterization of bioglass / maltodextrin nanocomposites in the presence of PVP as a potential candidate for flutamide drug delivery

سال انتشار: 1401
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 28

فایل این مقاله در 12 صفحه با فرمت PDF قابل دریافت می باشد

این مقاله در بخشهای موضوعی زیر دسته بندی شده است:

استخراج به نرم افزارهای پژوهشی:

لینک ثابت به این مقاله:

شناسه ملی سند علمی:

JR_IJND-13-4_003

تاریخ نمایه سازی: 12 مهر 1401

چکیده مقاله:

Bioactive glass is an appropriate substance for the transporting a pharmaceutical compound owing to its special effects (containing great antibacterial, semiconducting, nanoporous, adherent, and strong bonding with the bone tissue). Hence, in recent years, many investigations have been done in this topic. However, several constraints alike fast drug release and slow drug loading ability are observed in preceding researches. The researchers proposed that restrictions can be resolved by improving the fabricating method of bioglass and the reinforcement of diverse nanocomposites for postponing drug release. Therefore, new bioglass/maltdextrin nanocomposites were created via the sol-gel procedure in the absence and presence of Polyvinylpyrrolidone (PVP) as an organic modifier. bioglass/maltdextrin nanoparticles and bioglass/maltdextrin/PVP nanocomposites were characterized by (XRD) technique, (EDX), (FE-SEM) and (FT-IR). Moreover, the loading of flutamide and release behavior at pH = ۷.۴ and T = ۳۷ °C of the provided specimens were determined by UV-Vis Spectroscopy. The effects of flutamide Loading on the bioglass/maltdextrin/PVP nanocomposites at different times (۶, ۸, ۲۴ and ۷۲ hrs.) were investigated. Also, the structural properties of bioglass / maltodextrin / PVP nanocomposites on loading and release of flutamide were evaluated. The capability of nanocomposites for flutamide delivery was surveyed as a drug delivery pattern under in vitro condition. Percentage of Drug loading efficiency on nanocarriers ۹۹.۸۹% was acquired, and eventually the release rate was reduced slowly up to nearly ۱۲ days. Accordingly, the outcomes ascertained that the bioglass/maltdextrin/PVP nanocomposites with the high loading performance and stable release ability can be appropriate candidates for sustained flutamide release.

نویسندگان

Masumeh Tajik

Department of Chemistry, Science and Research Branch, Islamic Azad University, Tehran, Iran.

Mirabdullah Seyed Sadjadi

Department of Chemistry, Science and Research Branch, Islamic Azad University, Tehran, Iran.

Karim Zare

Department of Chemistry, Science and Research Branch, Islamic Azad University, Tehran, Iran.

Nazanin Farhadyar

Department of Chemistry, Varamin Pishva Branch, Islamic Azad University, Varamin, Iran.

مراجع و منابع این مقاله:

لیست زیر مراجع و منابع استفاده شده در این مقاله را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود مقاله لینک شده اند :
  • Durgalakshmi D., Subhathirai S. P., Balakumar S., (۲۰۱۴), Nano-bioglass: A ...
  • Widiyanti S., (۲۰۲۰), Synthesis of nano bioactive glass or bioglass. ...
  • Chai C., Leong K. W., )۲۰۰۷(, Biomaterials approach to expand ...
  • Miao X., Tan D. M., Li J., Xiao Y., Crawford ...
  • Kuzmenka D., Sewohl C., König A., Flath T., Hahnel S., ...
  • Huang L. D., Gong W. Y., Dong Y. M., (۲۰۲۱), ...
  • Sedighi O., Alaghmandfard A., Montazerian M., Baino F., (۲۰۲۲), A ...
  • Gerasymchuk Y., Wedzynska A., Lukowiak A., (۲۰۲۲), Novel CaO–SiO۲–P۲O۵ nanobioglass ...
  • Pajares Chamorro N., Wagley Y., Hammer N., Hankenson K., Chatzistavrou ...
  • Correia B. L., Gomes A. T., Noites R., Ferreira J. ...
  • Vale A. C., Pereira P. R., Barbosa A. M., Torrado ...
  • Chen Q., Roether J. A., Boccaccini A. R., (۲۰۰۸), Tissue ...
  • Boccaccini A. R., Erol M., Stark W. J., Mohn D., ...
  • Sepulveda P., Jones J. R., Hench L. L., (۲۰۰۱), Characterization ...
  • Brunner T. J., Grass R. N., Stark W. J., (۲۰۰۶), ...
  • Sarkar S. K., Lee, B. T., (۲۰۱۱), Synthesis of bioactive ...
  • Leite Á. J., Mano J. F., (۲۰۱۷), Biomedical applications of ...
  • Sharma A., Jain C. P., (۲۰۱۰), Preparation and characterization of ...
  • Saroj A. L., Singh R. K., Chandra S., (۲۰۱۳), Studies ...
  • Bui X. V., Ngo T. M. T., (۲۰۲۰), Synthesis and ...
  • Ramteke S. P., Muley G. G., Baig M. I., Ibrahim ...
  • Anis M., Muley G. G., Baig M. I., Khan W. ...
  • Baig M. I., Hussaini S. S., Ali H. E., Anis ...
  • Aslibeiki B., Kameli P., Salamati H., Eshraghi M., Tahmasebi T., ...
  • Meskinfam M., Sadjadi M. S., Jazdarreh H., (۲۰۱۱), Biomimetic preparation ...
  • Sahba R., Seyed Sadjadi M., Sajjadi A. A., Farhadyar N., ...
  • Rahma A., Munir M. M., Prasetyo A., Suendo V., Rachmawati ...
  • Senthilkumar S. R., Sivakumar T., (۲۰۱۴), Green tea (Camellia sinensis) ...