Synthesis and characterization of bioglass / maltodextrin nanocomposites in the presence of PVP as a potential candidate for flutamide drug delivery

Bioactive glass is an appropriate substance for the transporting a pharmaceutical compound owing to its special effects (containing great antibacterial, semiconducting, nanoporous, adherent, and strong bonding with the bone tissue). Hence, in recent years, many investigations have been done in this topic. However, several constraints alike fast drug release and slow drug loading ability are observed in preceding researches. The researchers proposed that restrictions can be resolved by improving the fabricating method of bioglass and the reinforcement of diverse nanocomposites for postponing drug release. Therefore, new bioglass/maltdextrin nanocomposites were created via the sol-gel procedure in the absence and presence of Polyvinylpyrrolidone (PVP) as an organic modifier. bioglass/maltdextrin nanoparticles and bioglass/maltdextrin/PVP nanocomposites were characterized by (XRD) technique, (EDX), (FE-SEM) and (FT-IR). Moreover, the loading of flutamide and release behavior at pH = ۷.۴ and T = ۳۷ °C of the provided specimens were determined by UV-Vis Spectroscopy. The effects of flutamide Loading on the bioglass/maltdextrin/PVP nanocomposites at different times (۶, ۸, ۲۴ and ۷۲ hrs.) were investigated. Also, the structural properties of bioglass / maltodextrin / PVP nanocomposites on loading and release of flutamide were evaluated. The capability of nanocomposites for flutamide delivery was surveyed as a drug delivery pattern under in vitro condition. Percentage of Drug loading efficiency on nanocarriers ۹۹.۸۹% was acquired, and eventually the release rate was reduced slowly up to nearly ۱۲ days. Accordingly, the outcomes ascertained that the bioglass/maltdextrin/PVP nanocomposites with the high loading performance and stable release ability can be appropriate candidates for sustained flutamide release.

کلیدواژه ها:

Efficiency ، nanoparticles ، prostate cancer ، Release ، sol-gel