The effects of Circuit resistance training on serum CTRP۵ and CTRP۱۲ in obese men

Obesity contributes to a state of chronic low-grade inflammation, with altered production and function of adipokines. Exercise health benefits are partly mediated by exertional changes in several adipokines. Secreted C۱q/TNF-related proteins (CTRPs) are one such group of regulators that regulate glucose, insulin sensitivity and fat metabolism in peripheral tissues and modulate inflammation in adipose tissue. CTRP-۵ and CTRP۱۲ are a promising target for the treatment of chronic low-grade inflammation-related diseases that opening up a new therapeutic avenue for the treatment of obesity.The aim of this study was to investigate effect of Circuit resistance training (CRT) on CTRP۵, CTRP۱۲ on modulate inflammation in adipose tissue.In this study, ۲۲ obese man in the age range of ۲۳-۳۲ years old randomly divided into two groups including one groups of resistance training (n=۱۱) and one control group (n=۱۱). Exercises in CRT protocol included back squats, lat pulldown, leg press, chest press, leg extension, leg curls lateral raise, standing calf raise, biceps curl, triceps push down, and abdominal crunch. the CRT protocol included three circuits of ۱۰ exercises, at an intensity of ۵۰% of ۱-RM, ۱۴ repetitions with a minimum rest (< ۱۵ s) between exercises and ۳ min rest between sets. Blood samples were taken before and ۷۲ hours after the last training session and were used to analyze the factors. For comparison between groups, two-way analysis of variance and Bonferroni post hoc test were used and for intragroup changes T test was used at a significant level (P <۰.۰۵).After ۱۲ weeks, the results showed that CTRP-۵ (p <۰.۰۰۱) and CTRP۱۲ (p <۰.۰۰۱) had increase compared to controls.This results demonstrated that after ۱۲ weeks, CTRP۵ and CTRP۱۲ levels increased. So CTRP۵ and CTRP۱۲ are novel metabolic/immune regulator linking obesity to adipose tissue inflammation and insulin resistance.

کلیدواژه ها:

Inflammation ، Obesity ، Adipose tissue