Effect of ۱۰ Weeks Continuous and Interval Moderate-Intensity Endurance Training on Serum Levels of Glial Cell-Derived Neurotrophic Factor and Brain Derived Neurotrophic Factor in Overweight Children

Regular exercise is an important behavioral procedure to reduce the incidence of various neurological diseases, including Alzheimer s, Parkinson s and Huntington s diseases, improves brain health and increasing neurotrophins. Neurotrophins, especially brain-derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF) are essential functional regulators of neurons and cell survival. The aim of this study was to investigate the effect of continuous and interval moderate-intensity endurance training on serum levels of glial cell-derived neurotrophic factor and brain derived neurotrophic factor in overweight students.۲۱ students (sedentary and BMI> ۲۵) were divided into three groups: control, continuous and interval aerobic groups. Subjects were boys aged ۱۲ to ۱۵ years Training protocol carry out for ۱۰ weeks and three sessions per week, each session lasting ۶۰ minutes. Blood samples were taken from the participants ۴۸ hours before and after the training protocol, and the content of GDNF and BDNF was examined by ELISA. The results were evaluated using SPSS software version ۱۶ at the level of α <۰.۰۵.The results showed that ۱۰ weeks of continuous and interval training, significantly increased the maximum oxygen consumption of overweight boys (P≤ ۰.۰۵). ANOVA analysis did not show a significant difference in BDNF and GDNF content between the experimental and control groups. Also, the slight increase of BDNF and GDNF content in the post-test compared to the pre-test was not significant in any of the experimental groups (P <۰/۰۵).Although continuous and interval aerobic training can improve aerobic fitness in overweight students, but no significant effect on their GDNF and BDNF serum levels.

کلیدواژه ها:

Interval Endurance Training ، Continuous endurance training ، Glial Cell-Derived Neurotrophic Factor ، Brain Derived Neurotrophic Factor ، VO۲max