Evaluation of KATP response on protection of heart tissue in male rats after resistance training

Due to the widespread global prevalence of coronary artery disease, it is important to provide a strategy to protect the heart from injury. Increasing the function of ATP-sensitive potassium channels is a specific mechanism of heart protection that is achieved through regular exercise. Research has shown that physical activity exerts its vasodilatory effect mainly in the coronary artery through calcium-sensitive potassium channels, as well as the presence of different subunits of ATP-sensitive potassium channels required for vasodilating effects in sports vessels. IsThe aim of this study was to evaluate the KATP response of ATP-sensitive potassium channels to the protection of heart tissue in male rats after eight weeks of resistance training.The present study was an experimental study consisting of ۱۰ healthy male Wistar rats with a mean weight of ۱۵۰ ۷۰ ۷۰ which were randomly divided into control and resistance training groups. The resistance training group performed the training protocol for ۸ weeks. For immunohistochemical tests, the heart tissue was measured and the level of potassium channel proteins (KIR۶.۲, SUR) in the left ventricle of the tissue was measured. Independent t-test was used to analyze the data. Significance level was considered less than ۰.۰۵.After ۸ weeks of resistance training, it was shown that the expression of potassium channel proteins (KIR۶.۲, SUR) in the resistance training group was higher than the control group (P = ۰.۰۰۱).It seems that resistance training by manipulating the ATP mechanism increases the number of ATP-sensitive potassium channels in the heart tissue, which ultimately leads to a reduction in tissue damage

کلیدواژه ها:

Resistance training ، Potassium channel ، Heart tissue