In vitro assessment of Valproic acid cytotoxicity on HepG۲

The hepatotoxicity induced by valproic acid (VPA) has been described in many clinical studies. The objective of this study is to investigate the hepatotoxicity of valproic acid on human hepatoma carcinoma cell line HepG۲. The cell viability was evaluated by MTT assay, and treatment with valproate sodium significantly decreased the viability of HepG۲ cells.

کلیدواژه ها:

Valproic acid ، MTT assay ، HepG۲ ، Hepatotoxicity ، DILI