LSPR based biosensor for pancreatic cancer’s detection

This work reports the fabrication of gold nanoparticles on a glass substrate via a high-temperature annealing method for designing a localized surface plasmon resonance (LSPR) biosensor. To obtain gold nanoparticles, a thin film of gold with different thicknesses has been deposited on a glass substrate using the magnetron sputtering method. Then, an eight-hour annealing process has been performed at different temperatures close to the glass transition temperature to form gold nanoparticle islands on the glass substrate. Then, CA-۱۹-۹ antibodies are immobilized on gold nanostructures and the identification of the specific antigens are evaluated by the corresponding wavelength shift in LSPR peak wavelength and the light intensity changes.

کلیدواژه ها:

Gold Nano-Structured Substrates ، Localized Surface Plasmon Resonance ، Thermal Annealing ، Optical Biosensor