Genome-wide association study and gene ontology for growth and wool characteristics in Zandi sheep

سال انتشار: 1399
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 204

فایل این مقاله در 11 صفحه با فرمت PDF قابل دریافت می باشد

استخراج به نرم افزارهای پژوهشی:

لینک ثابت به این مقاله:

شناسه ملی سند علمی:

JR_KLST-8-2_006

تاریخ نمایه سازی: 14 دی 1400

چکیده مقاله:

Genome-wide association studies (GWAS) is a major procedure for studying the genetics of complex economically important traits in sheep. The objective of this study was to determine the genomic regions affecting some growth traits and wool characteristics in Zandi sheep. This study is GWAS implementing a medium-density single nucleotide polymorphism (SNP) panel to determine the putative chromosome area affecting some growth and wool traits in a fat-tailed sheep breed, simultaneously. We used a selective genomic approach sampling DNA from animals at the extreme ends using the estimated breeding values derived from a total population size of over ۵,۰۰۰ animals. The examined phenotypic data included the birth weight, weaning weight, ۶, ۹, and ۱۲-months after birth weight, pre- and post-weaning average daily gain, fiber diameter (micron), prickle factor (%), staple length (mm), kemp (%) and medullated fiber. Genome-wide association analyses were performed based on the mixed linear model. Twenty-three regions, in which four were associated with more than one trait, located on ۱۲ chromosomeswere associated with the studied growth and wool traits (p <­۵×۱۰−۶). These genomic regions overlapping with KCNIP۴, PPARGC۱A, ASAP۱, ANK۲, WWOX, SYNE۱, FBXO۵, AKAP۶, FABP۳, ANGPTL۴, ATP۶V۱B۲, PARK۲, and KRTAP۱۱-۱ genes, were associated with postnatal growth, regulation of metabolic pathways, skeletal muscle differentiation, and bone growth. Gene ontology term enrichment analysis revealed that genes involved in positive regulation of muscle structure, and muscle tissue development were over-represented in the identified candidate genes.

نویسندگان

Hossein Mohammadi

Department of Animal Science, Faculty of Agricultural Sciences, University of Tabriz, Tabriz, East Azerbaijan, Iran.

Seyed Abbas Rafat

Department of Animal Science, Faculty of Agricultural Sciences, University of Tabriz, Tabriz, East Azerbaijan, Iran.

Hossein Moradi Shahrbabak

Department of Animal Sciences, University College of Agriculture and Natural Resources, University of Tehran, Karaj, Alborz, Iran.

Jalil Shodja

Department of Animal Science, Faculty of Agricultural Sciences, University of Tabriz, Tabriz, East Azerbaijan, Iran.

Mohammad Hossein Moradi

Department of Animal Sciences, Faculty of Agriculture and Natural Resources, Arak University, Arak, Markazi, Iran.

مراجع و منابع این مقاله:

لیست زیر مراجع و منابع استفاده شده در این مقاله را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود مقاله لینک شده اند :
  • Abdoli, R., Mirhoseini, S., Hossein-Zadeh, N.G., Zamani, P., Moradi, M.H., ...
  • Al-Mamun, H.A., Kwan, P., Clark, S.A., Ferdosi, M.H., Tellam, R., ...
  • Bohlouli, M., Mohammadi, H., Alijani, S., ۲۰۱۳. Genetic evaluation and ...
  • Bolormaa, S., Hayes, B.J., van der Werf, J.H.J., Pethick, D., ...
  • Cavanagh, C.R., Jonas, E., Hobbs, M., Thomson, P.C., Tammen, I., ...
  • Chang, C.C., Chow, C.C., Tellier, L.C.A.M., Vattikuti, S., Purcell, S.M., ...
  • Ebrahimi, F., Gholizadeh, M., Rahimi-Mianji, G., Farhadi, A., ۲۰۱۷. Detection ...
  • Esfandyari, H., Aslaminejad, A.A., Rafat, S.A., ۲۰۱۷. Wool characteristics in ...
  • Esmailizadeh, A.K., ۲۰۱۰. A partial genome scan to identify quantitative ...
  • Gholizadeh, M., Rahimi-Mianji, G., Nejati-Javaremi, A., ۲۰۱۵. Genomewide association study ...
  • He, L.C., Li, P.H., Ma, X., Sui S.P., Gao ,S., ...
  • Hu, Z.L., Park, C.A., Reecy, J.M., ۲۰۱۶. Developmental progress and ...
  • Huang, D.W., Sherman, B.T., Lempicki, R.A., ۲۰۰۹. Systematic and integrative ...
  • Matika, O., Riggio, V., Anselme-Moizan M., Law A.S., Pong-Wong R., ...
  • Mohammadi, H., Rafat, S.A., Moradi Shahrebabak, H., Shodja, J., Moradi, ...
  • Pasandideh, M, Rahimi-Mianji G, Gholizadeh, M., ۲۰۱۸. A genome scan ...
  • Pasandideh, M., Gholizadeh, M., Rahimi-Mianji, G., ۲۰۲۰. Identification of two ...
  • Ponz, R., Moreno, C., Allain, D., Elsen, J.M., Lantier, F., ...
  • Purcell, S., Neale, B., Todd-Brown, K., Thomas, L., Ferreira, M.A.R., ...
  • Rogers, M.A., Langbein, L., Winter, H., Ehmann, C., Praetzel, S., ...
  • Wang, Z., Zhang, H., Yang, H., Wang, S., Rong, E., ...
  • Weng, Z., Su, H., Saatchi, M., Lee, J., Thomas, M.G., ...
  • Xu, S.S., Ren, X., Yang, GL., Xie, X.L., Zhao, Y.X., ...
  • Zhang, H., Wang, Z., Wang, S., Li, H., ۲۰۱۲. Progress ...
  • Zhang, L., Liu, J., Zhao, F., Ren, H., Xu, L., ...
  • نمایش کامل مراجع