Spectrophotometery stud ies on the interaction of new complex, tribromo phenantridin e aurum (III), with calf thymus DNA

Nucleic acids play a n important role in bio logical syst ems and carry out a broad range of biologica l functions. Increasing interest is being shown in DNA because of their applicatio n in vario us type of therapy [۱]. The biological function of DNA is often dependent o n interactio ns with different moieties such as metal ions [۲, ۳]. DN A structure can underg o conform ational changes due to ligand binding. Metal ions are imp ortant cofa ctors in DNA structures and function, facilitating the double helical structure stabilization and catalysis [۴ ]. Also the extent of hydration of cations bou nd to DNA is a key parameter in th e energies of the binding process as well as a relevant iss ue in the ca talytic role s and struct ural effects of bound ions. An understanding of the factors involved in metal ion–DNA interaction is thus of consider able importance.

کلیدواژه ها:

Calf-thymus DNA ، (phend) Br ۳ -Au (III) ، Interaction ، Sp ectroscopy