Q SAR studies on some marine natural al kaloids a s anticancer agents in cancer leuke mia

Alkal oids are naturally oc curring nitrogen conta ining biol ogically ac tive hetero cyclic comp ounds. Over the last few years, a large number of biologically importa nt alkaloids with antivi ral, antibacterial, anti-i nflammatory , antimalar ial, antioxidant and anticancer activities have been isolated from marine source [۱]. Since an cient times nature has been a sour ce of medicines to cure many deadly diseases. Majority of drugs in use today are either natural products (NP), t heir derivatives (ND), natural pro ducts mimics (NPD) or semisynthetic derivatives (SSD) [۲]. The outcomes of patients age ۶۰ years and older with acute my eloid leuke mia (AML) treated wit h conventional cytotox ic chemothe rapy remai n poor, wit h few long-term survivors, irrespective of the in duction che motherapy provided and the intensity or duration of postremission treatment [۳].