The effect of Nickel (II) Schiff Base complex on the some blood parameters in diabetic rat (Wistar)

Schiff bases are a group of organic compounds with the C = N-R group that act as coordinate ligands and form stable complexes with metals. Due to the increasing use of Schiff base compounds in biology and treatment of incurable diseases, the effect of nickel (II) Schiff base complex in the treatment of diabetes was investigated in the present study. For this purpose, ۴۹ Wistar rats (۲۲۰-۲۰۰g) were divided into ۷ equal groups as control, receiver Schiff Base, receiver DMSO, diabetic without treatment, diabetic and receiver ۵mg/kg wb Glibenclamide, and two diabetic groups that were treated with ۵۰ and ۱۰۰ mg/kg bw of Nickel (II) Schiff Base solution by gavage. The rats were diabetic with single dose of streptozotocin (۸۰mg/kg bw). After treatment period (۴۰ days), blood samples were taken from rats, and serum biochemical parameters were measured with a special kit. The obtained data were statistically analyzed (P<۰.۰۵). The results showed a significant increase in level of glucose, liver enzymes and malondialdehyde in the untreated diabetic group compared to the control group, and their reduction in the groups that receiving Glibenclamide and Schiff base compared to the diabetic group. Also, there was no significant difference in concentration of the mentioned parameters between the groups treated with nickel and the group consuming Glibenclamide. According to the results, the synthetic compound of nickel (II) Schiff base complex is somewhat effective in improving the complications of diabetes in the liver via glucose reduction at a level comparable to Glibenclamide as a antidiabetic drug. Therefore, further research is recommended, maybe offer a way in diabetes treatment.

کلیدواژه ها:

Alkaline phosphatase enzyme ، Alanin Aminotransferase ، Salen ligand ، Metal complex