Involvement of D۱/D۲ Receptors on ۱-Methyl-Β-Carboline (Harmane) Induced-Amnesia in the Step-Down Passive Avoidance Test

سال انتشار: 1389
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 269

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شناسه ملی سند علمی:

JR_ZUMS-18-72_001

تاریخ نمایه سازی: 11 اردیبهشت 1400

چکیده مقاله:

Background and Objective: A number of β-carboline alkaloids such as harmane are naturally present in the human food chain. In the present study the involvement of dopaminergic system on harmane induced-amnesia was investigated. Materials and Methods: One-trial step-down paradigm was used for the assessment of memory retention in adult male NMRI mice. Results: Intraperitoneal (i.p.) administration of harmane (۵ and ۱۰ mg/kg) immediately after training, dose-dependently decreased memory formation. Administration of D۱/D۲ receptors agonist, apomorphine (۰.۵ and ۱ mg/kg, i.p.) before testing by itself could not alter memory retrieval. On the other hand, in the animals in which memory formation was impaired due to harmane post-training administration, pre-test administration of apomorphine (۰.۵ and ۱ mg/kg, i.p.) ۲۴ hr after training in day’s test restored memory. Furthermore, administration of SCH۲۳۳۹۰ (۰.۰۲۵, ۰.۰۵ and ۰.۱ mg/kg, i.p.) or sulpiride (۱۲.۵, ۲۵ and ۵۰ mg/kg, i.p.) before testing by itself could not alter memory retrieval, respectively. On the other hand in the animals in which memory formation was impaired due to harmane post-training injection, pre-test administration of SCH۲۳۳۹۰ (۰.۰۵ and ۰.۱ mg/kg) or sulpiride (۲۵, ۵۰ mg/kg, i.p.) ۲۴ hr after training in day’s test decreased hamane-induced amnesia. Conclusion: These findings indicat the involvement of D۱/D۲ receptors in harmane induced-amnesia through different mechanism(s).

کلیدواژه ها:

Keywords: Harmane ، Apomorphine ، SCH۲۳۳۹۰ ، Sulpiride ، Step-down passive avoidance task ، Mice

نویسندگان

محمد ناصحی

Islamic Azad University, Garmsar Branch, Semnan, Iran

مرتضی پیری

Islamic Azad University, Ardabil Branch, Ardabil, Iran

مریم السادات شاهین

Islamic Azad University- Shahr-e-rey Branch, Tehran, Iran

محمدرضا زرین دست

Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran