The effect of regular resistance exercise, vitamin D, and calcium supplements on the gastrocnemius muscle in rats in the post-menopausal period: An experimental study
محل انتشار: مجله طب تولید مثل ایران، دوره: 19، شماره: 3
سال انتشار: 1399
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 288
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شناسه ملی سند علمی:
JR_IJRM-19-3_008
تاریخ نمایه سازی: 17 فروردین 1400
چکیده مقاله:
Background: Menopause is the natural termination of menstruation which affects the quality and important aspects of womenchr('39')s life.
Objective: To evaluate the effect of regular resistance training (Ex) with vitamin D (Vit. D) and calcium (Ca) supplements in the postmenopausal period on muscle tissue in rats.
Materials and Methods: In this experimental study, 72 female Wistar rats (8-10-wk old) were randomly divided into control, placebo, Vit. D, Ca, Ex, Ca + Vit. D, Ex + Ca, Ex + Vit. D, and Ex + Ca + Vit. D groups. Control and placebo groups were fed with a standard diet and sesame oil, respectively. Two month after the ovariectomy, Ex, Ca (35 mg/kg), and Vit. D (10000 IU) were administred in all groups except the control. The number of muscle and inflammatory cells, fiber diameter, endomysium thickness, and degenerative collagen fiber area were assessed through hematoxylin-eosin staining.
Results: Muscle cell number was increased in the Ex + Vit. D + Ca, Vit. D + Ex, and Vit. D groups compared to the control group; also, inflammatory cell number showed significant increase in the Ex + Vit. D + Ca (12 ± 5.46), Vit. D + Ex (14 ± 3.25), Ex (13 ± 4.08), Vit. D (11 ± 3.26), Ca + Vit. D (10 ± 1.01), and Ca + Ex (9 ± 2.87) groups. Muscle fiber diameter in the Ex + Vit. D + Ca and Vit. D + Ex groups was higher than the other groups. Endomysium thickness was significantly decreased in the Ex + Vit. D + Ca and Vit. D + Ex groups compared to the control and placebo groups (p < 0.001). Degenerative collagen fiber area showed a significant increase in the Ex + Vit. D + Ca and Vit. D + Ex groups (p ≤ 0.001) comparison with the control group.
Conclusion: Regular resistance exercise, Vit. D, and Ca supplements can improve muscle morphological features in the postmenopausal period.
کلیدواژه ها:
نویسندگان
Seyedeh Zahra Hosseini Sisi
Department of Exercise Physiology, Central Tehran Branch, Islamic Azad University, Tehran, Iran.
Mohammad Ali Azarbayjani
Department of Exercise Physiology, Central Tehran Branch, Islamic Azad University, Tehran, Iran.
Mohammadreza Vafaeenasab
Yazd Cardiovascular Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Maghsoud Peeri
Department of Exercise Physiology, Central Tehran Branch, Islamic Azad University, Tehran, Iran.
Mohammadreza Dehghani
Yazd Medical Genetic Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
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