Highly Efficient and Reusable MCM-41-Immobilized 2‐(Methylthio)cyclohexanone Copper(I) Catalyst for the Sonogashira Coupling of Arylhalides with Phenylacetylene

Catalytic methods including the C-C bond formation reactions have been appeared as most multipurpose and influential tool for the production of value added A useful and effective technique for carbon-carbon bond constructions is c opper catalyzed Sonogashira coupling reaction that plays a key role in contemporary synthetic chemistry. In fact Sonogashira coupling products that consist of a triple bond into aromatic systems are building blocks for an extensive range of natural and pharmaceuticals materials.A highly efficient MCM-41-immobilized 2-(methylthio)cyclohexanone copper(I) complex [Cu(I)-2-MCH@MCM-41] was prepared from 2‐(methylthio)cyclohexanone via immobilization on mesoporous material MCM-41, followed by reacting with CuI. The catalyst was applied for the C−C cross-coupling reaction of aryl halides with phenylacetylene. Corresponding products were produced in good to excellent yields in N2 atmosphere. The catalyst could be recovered and recycled for several consecutive runs[1-3].

کلیدواژه ها:

Sonogashira ، MCM-41 ، C-C coupling ، Arylhalides ، Heterogeneous