MBD1 Expression and its correlation with Clinicopathological Prognostic Factors

Background: MBD1, named methyl-CpG binding protein 1, is a transcriptional repressor and belongs to one member of methyl-CpG binding domain (MBD) family. This protein can regulate both gene expression and methylation level and contribute to the tumor growth in colorectal cancer (CRC). The aim of this study was to examine MBD1expression in patients with CRC and evaluate its potential correlations with clinicopathological factors.Material and Methods: immunohistochemistry was performed to examined the MBD1 protein expression in 60 cases of CRC tissue samples and their corresponding neighboring normal tissues as control samples. In the next step, the correlation of MBD1 with clinicopathological features of patients including sex, gender, stage, location, type of the tumor, grade and metastasis were assessed.Results: The expression of MBD1 Protein downregulate significantly in cancer samples compared to normal control samples. This downregulation increased correspond to metastasis and grade of cancer, however no correlation was seen between the expression of MBD1 and sex, gender, stage, location and type of the tumor.Conclusion: Our data suggest that reduced expression of MBD1 may be contribute to tumor genesis. However, the use of this protein as a prognostic factor requires further research on larger volume samples.

کلیدواژه ها:

MBD1 ، clinicopathological features ، Colorectal Cancer