HN-01510086_The Effect of Coenzyme Q10 Supplementation on Serum Levels of Lactate, Pyruvate, Matrix Metalloproteinase 9 and Nitric Oxide in Migraineur Women. A Double Blind, Placebo, Controlled Randomized Clinical Trial.

Introduction: The purpose of this study was to investigate the effect of coenzyme Q10 (CoQ10) supplementation on levels of lactate, pyruvate Matrix metalloproteinase 9 (MMP-9) and nitric oxide (NO) in women with migraine.Methods: This randomized, double-blind, placebo-controlled clinical trial was performed among 46 patients diagnosed with migraine. Subjects were randomly assigned to placebo group (n=23) and/or intervention group (n=23), supplemented with 400 mg/day of CoQ10. The duration of the intervention was 12 weeks. Blood samples were collected at baseline and at the end of the intervention, in order to measure serum levels of CoQ10, lactate, pyruvate, MMP-9 and NO. Lactate/pyruvate ratio was calculated as serum lactate divided by serum pyruvate.Results: Treatment with CoQ10 significantly reduced lactate, and pyruvate. Serum concentrations of MMP-9 and NO decreased while serum CoQ10 concentrations increased in CoQ10-treated group after 12 weeks. There was a significant reduction in LP ratio in intervention group. None of these changes had been observed in placebo treated group (p> 0.05). In the other hand, the inter-group statistical analysis revealed CoQ10 significantly increase serum levels of CoQ10 and decrease MMP-9, NO, pyruvate and lactate compared with the placebo-receiving group. The study results showed CoQ10 supplementation significantly decrease frequency, severity and duration of migraine attacks compared with placebo receiving group (p<0.05).Conclusion: In the current trial, 12 weeks of oral CoQ10 supplementation demonstrated positive effects on mitochondrial function, serum levels of NO and MMP-9 as an involvement factors in the pathophysiology of migraines.

کلیدواژه ها:

Coenzyme Q10 ، Mitochondrial dysfunction ، Lactate ، Pyruvate ، Matrix metalloproteinase 9 ، Nitric oxid