HN-01050092_Association of plasma fatty acids pattern and omentin gene expression in visceral and subcutaneous adipose tissue: A cross-sectional study

Introduction: omentin, as an adipokine have been reported to improve insulin resistance and inflammation may be related to fatty acids (FAs). plasma FA can be used as biomarkers of dietary FA and of endogenous FA exposure. Concentrations of FA highly correlate and may interact with each other, thus may be missed by examining individual FA. We aimed to evaluate the association between plasma FA patterns and omentin gene expression in adipose tissue (AT).Methods: Visceral and subcutaneous AT and fasting blood were gathered from 97 adults aged 18-82 years, who had undergone elective abdominal surgery. Dietary intakes were assessed using a food frequency questionnaire. The relative omentin gene expression in visceral and subcutaneous AT was measured by Real-Time PCR and plasma FAs was determined by gas chromatography. principal component analysis was performed to derive FAs pattern from 18 plasma individuals FAs.Results: Three pattern were derived from plasma FAs, 1) high de novo lipogenesis FAs, 2) high trans saturated fatty acids (SFA) and docosahexaenoic acid, 3) high long-chain SFA. After adjustment for confounders, only the long-chain SFA pattern was associated with omentin gene expression in visceral AT (p = 0.03, β = 2.25). The other patterns were not associated with omentin gene expression in visceral and subcutaneous AT.Conclusion: Our findings suggested that plasma FA pattern may be associated with omentin gene expression. Specifically, a pattern characterized by high levels of long-chain SFA was related with omentin gene expression in visceral AT.