Effect of intraventricular injection of Neuregulin1β on emotional stress in Alzheimer model of rats

Background and Aim : Neuregulin-1β (NRG1 β) is associated with various neurological disorders such as schizophrenia, depression and Parkinson s disease. However, its role in Alzheimer s (AD) has not been understood yet. Here, we have studied the effect of NRG1β and extracellular-signal-regulated kinase (ERK) signaling on emotional stress in AD model of rats.Methods : Fifty six male Wistar rats were divided into eight groups of: Saline + Saline, Aβ+Saline, Aβ+NRG1β (5μg/5ul), Aβ+PBS, Aβ+NRG1β+PD98059 (PD, 5 μg/2 μl), Aβ+NRG1β+Saline and Saline+PD. AD model was induced by intracerebroventricular (ICV) injection of beta-amyloid protein (Aβ1-42, 4 μg/2 μl). The locomotors activity and emotionality of animals were considered in an Open field test. Data were analyzed by one way Anova and T-test.Results : No significant between groups differences was found in emotional stress characteristics in open field, except the grooming numbers which were higher in Saline + PD compared with Saline + Saline (p=0.02).Conclusion : Our findings indicate that NRG1β restores cognitive dysfunctions induced by amyloid β through signaling pathways with no significant change in anxiety, locomotion and vegetative activities.

کلیدواژه ها:

Alzheimer diseases ، Rat ، neuregulin1beta ، Open field