Ethylene glycol coated magnetic graphene oxide nanocomposite for MRI

Nano graphene oxide is a good candidate for medical imaging purposes including magnetic resonance imaging (MRI). Thanks to the two dimensional layer structure of graphene oxide with high surface area, magnetic nanoparticles which are used in MRI can be placed on graphene oxide nanosheet [1]. Since magnetic nanoparticles can be toxic for medical purposes, placing of the nanoparticles on graphene oxide layers leads to less toxicity of them for biological conditions [2]. Additionally, usage of coating material around magnetic graphene oxide nanocomposite provides more biocompatibility and possibility of surface functionalization. The aim of this research was to investigate ability of ethylene glycol coated magnetic graphene oxide nanocomposite for using in MRI.Magnetic graphene oxide was prepared with hydrothermal method and the structure, size, morphology, and cell toxicity was determined by use of XRD, TEM, SEM and MTT assay analyzes. In vitro MRI was carried out with a 1.5 tesla medical system and signal changes of the nanocomposite samples which were dispersed in agar were determined.The results showed successfully prepared ethylene glycol coated magnetic graphene oxide nanocomposite with layer structure. No toxic effect on the cell culture was seen. The samples with higher amount of the magnetic graphene oxide nanocomposite showed higher signal changes relative to the control.In conclusion, ethylene glycol coated magnetic graphene oxide nanocomposite is suitable for signal changing in MRI.