Evaluating the clinical effectiveness of stem cell transplantation in the treatment of acute leukaemia: a systematic review

سال انتشار: 1398
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 298

نسخه کامل این مقاله ارائه نشده است و در دسترس نمی باشد

استخراج به نرم افزارهای پژوهشی:

لینک ثابت به این مقاله:

شناسه ملی سند علمی:

SRMMED22_426

تاریخ نمایه سازی: 19 آبان 1398

چکیده مقاله:

Background and Objective: Acute leukaemia is a family of serious progressing cancers of bone marrow which is divided into acute myeloid leukaemia (AML) or acute lymphoblastic leukaemia (ALL). Hematopoietic stem cell transplantation (HSCT) is the transplantation of multipotent hematopoietic stem cells which may be replacement for conventional chemotherapy to improve survival and quality of life. The aim of this study is to evaluate the clinical effectiveness of SCT in the treatment of acute leukemia.Search Method: Databases, including PubMed, MEDLINE and Google scholar were searched from 2000 to 2017 for identifying published systematic reviews and meta-analyses. Ultimately 15 articles were selected that included randomized controlled trials (RCTs) and donor versus no donor (DvND) studies which patient groups were categorized related to 12 decision problems (DPs): DP1 related to SCT in adults with AML in first complete remission (CR1); DP2 to adults with AML in second remission (CR2+); DP3 to children with AML in CR1; DP4 to children with AML in CR2+; DP5 to adults with ALL in CR1; DP6 to adults with ALL in CR2+; DP7 to children with ALL in CR1; DP8 to children with ALL in CR2+; DP9 to the according to different sources of stem cells in transplantation; DP10 to different conditioning diet; DP11 to the use of purging in autologous SCT; and DP12 for using of T-cell depletion in allogeneic SCT. Findings: DvND studies have included useful evidence for effectiveness of allogeneic SCT using stem cells from matched donors. These studies showed that the use of allogeneic SCT in DP1, DP3 and DP5. There was low evidence in DvND studies for all decision problems related to patient groups in CR2+ and conflicting evidence in DP7. RCTs showed best evidence for effectiveness of autologous SCT which was similar to or less effective than chemotherapy. There was not sufficient evidence for DPs 9–12 in reviews of RCTs. Conclusion: These evidence proposed that allogeneic SCT may be effective than chemotherapy in childhood AML in CR1, adult AML in CR1, and adult ALL in CR1. In contrast chemotherapy is equal to or more effective than autologous SCT.

نویسندگان

Fatemeh Yaghoubi

Department of Biochemistry, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

Fatemeh Yaghoubi

Student Research Committee, Shahid Sadoughi University of Medical Sciences, Yazd, Iran