Chrysin Impact on Brain Oxidative Damages Induced by Immobilization in Rat

The aim of the current investigation is evaluation of the impact of chrysin (CH) on brain oxidative damage induced following chronic stressin animal models. Materials and Methods: The rats were restrained for 1 hour daily for 3 weeks. During these weeks, all animals were daily injected with either vehicle or CH (10, 20, 30 μg/kg). Results: In the stressed animals that received vehicle, the MDA level was significantly higher (P<0.01) and the levels of GSH and antioxidant enzymes were significantly lower than the non-stressed animals (P<0.05). CHalso ameliorated the MDA and GSH content as well as antioxidant enzymes activities in stressed rats (p<0.05). be useful for the management of depressant-like effects induced by chronic stress via decreasing oxidative damage in the brain.