Effect of Pregabalin-Loaded Nanoparticles on Spatial Memory in Pentylenetetrazol- Induced Chemical Kindling Model of Epilepsy

Epilepsy is a public health problem and one of the most common and heterogeneous neurological disorders that has a social and economicimpact affecting 65 million people worldwide. One of the causes of epilepsy is oxidative stress. Oxidative stress caused cellular disorder, cellular damage and cell death via oxidation of lipids, nucleotides, proteins and finally the oxidation of protein caused changes in body enzymes. Also the oxidative stress caused spatial memory impairment. Pregabalin is used in the treatment of epilepsy, neuropathic pain and general anxiety disorder that has side effects and low half-life. With the help of nanotechnology, this effects can be reduced and more of the drug transmitted to the brain. The aim of this study was to transfer the nano carrier of pregabalin to the brain and survey its effect on memory and spatial learning in the epileptic model. Materials and Methods: In this study, animals were divided into 4 groups. The groups was treated with salin, pregabalin, pregabalin-loaded nanoparticles for 10 days. Epilepsy model was induced by i.p injection of PTZ everysecond day.Animal behaviors were checked for a period of 20 minute after each PTZ injection. Morris water maze task was used to assess the memory and spatial