Evaluation of the wound healing activity of Salix nigra by in vivo excision and incision

Wound healing by medicinal plants which have fewer side effects than chemical drugs has been on the increase. In our study, we evaluated cutaneous wound healing potential of Salix nigra aqueous extract ointment in rats. Materials and Methods: In vivo design, after creating the cutaneous wound on the back of the rats, the animals were randomly divided into four groups; untreated control, treatment with Eucerin ointment, treatment with 3% tetracycline ointment, treatment with 3% S. nigra aqueous extract ointment. The groups were treated for 30 days. For biochemical and histopathological analysis of the cutaneous wound healing trend, a 3x3 cm section was prepared from all dermal thicknesses at days 10, 20, and 30. The data were analyzed using one-way ANOVA followed by Duncan post hoc test. Findings: The use of S. nigra aqueous extract ointment in the treatment groups led to remarkable reduce (p<0.05) in the levels of wound area, total cells, neutrophil, lymphocyte, and macrophage, and remarkable increase (p<0.05) in the levels of wound contracture, hydroxyl proline, hexosamine, hexuronic acid, fibrocyte, and the rate of fibrocyte to fibroblast as compared to the control and basal ointment groups. Conclusion: According to the findings, S. nigra aqueous extract ointment can cure the cutaneous wound

کلیدواژه ها:

Salix nigra ، ointment ، wound healing