Hepatoprotective, nephroprotective, hematoprotective, immunoprotective, and gastroduodenal protective properties effects of aqueous extract of Fumaria officinalis in Wistar male rats

The recent studies have indicated the properties of plants in the prevention of gastroduodenal ulcers. Fumaria officinalis has been used in traditional medicine as a therapeutical supplement. The aim of our research was to survey the preventive property of aqueous extract of F. officinalis on ibuprofen-induced gastroduodenal ulcers by investigating the biochemical, hematological, immunological, and microscopic approaches in rats. Materials and Methods: In this study, 60 rats were used. The animals were randomly divided into six subgroups, including negative healthy control, untreated negative control, the positive control receiving omeprazole 60 mg/kg and three groups receiving the F. officinalis aqueous extract at 20, 60, and 180 mg/kg concentrations. After 14 days, gastroduodenal ulcers were caused by ibuprofen 400 mg/kg. Four hours after oral administration of ibuprofen, the rats were sacrificed and blood, stomach, and duodenum samples of them collected for biochemical, hematological, immunological, and microscopic parameters analysis. Findings: All doses of F. officinalis could significantly (p<0.05) reduce the raised levels of ALP, AST, ALT, GGT, cholesterol, LDL, triglyceride, total and conjugated bilirubin, urea, creatinine, IL1, IL6, IL12, IL 18, IFN-Y, and TNF-a and increase HDL, total protein, albumin, WBC, platelet, RBC, IL4, IL5, IL 10, IL 13, and IFN-a as compared to the untreated group. Also, aqueous extract of F. officinalis prevented significantly (p<0.05) gastroduodenal ulcers as compared to the untreated group. Conclusion: The obtained results indicated the hepatoprotective, nephroprotective, hematoprotective, immunoprotective, and gastroduodenal protective properties of F. officinalis aqueous extract

کلیدواژه ها:

Fumaria officinalis ، hepatoprotective ، nephroprotective ، hematoprotective ، immunoprotective ، gastroduodenal protective.ma