Simple synthesis of 1H-pyrazolo [1, 2-b] phthalazine-5, 10-dione derivatives catalyzed by MgO NPs as an eco-safe catalyst
محل انتشار: پنجمین کنفرانس بین المللی مهندسی شیمی و نفت
سال انتشار: 1398
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 323
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شناسه ملی سند علمی:
OGPCONF05_063
تاریخ نمایه سازی: 18 مرداد 1398
چکیده مقاله:
A clean and simple synthesis of 1H-pyrazolo [1, 2-b] phthalazine-5, 10-dione derivatives via one-pot four-component condensation reaction of phthalimide, hydrazine monohydrate, aromatic aldehyde derivatives and malononitrile in the presence of a catalytic amount of magnesium oxide nanoparticles (MgO NPs) as an efficient and eco-friendly catalyst under thermal and solvent-free conditions with good yields and short reaction times is developed. This present methodology has notable benefits such as highly efficient, non-toxic catalyst, one-pot, solvent-free conditions, simplicity of operation with no necessity of chromatographic purification steps and eco-friendly.
کلیدواژه ها:
Magnesium oxide nanoparticles (MgO NPs) ، 1H-pyrazolo [1 ، 2-b] phthalazine-5 ، 10-dione derivatives ، Solvent-free conditions ، Multi-component reaction.
نویسندگان
Farzaneh Mohamadpour
Young Researchers and Elite Club, Shiraz Branch, Islamic Azad University, Shiraz, Iran